Cardiovascular disease is the primary cause of human mortality and morbidity. This course builds on the introductory coverage of normal structure and function in Phase 1 and the understanding of pathological process from the “General Pathology” course to consider the disturbances to normal physiology and the specific changes in end- organ structure that ultimately lead to the pathological hallmarks of cardiovascular disease. The course deals with the study of pathophysiology of common and major diseases of the cardiovascular system, their clinical presentations, and the various approaches to treatment. The emphasis is on understanding pathophysiological mechanisms rather than on memorizing clinical details, but learning will be enhanced through integrated online tutorial and laboratory-based teaching modules that feature video interviews with patients, clinicians, caregivers and family. This will be complemented by clinical exposure to patients in hospital settings, and to observation of simulated cardiovascular disorders in the Simulation Centre.