Genomics
Long-read whole genome sequencing
Long-read whole genome sequencing is an advanced genomic technology that enables the sequencing of large DNA fragments (typically >10 kb) in a single read. It provides accuracy in detecting structural variations, resolving complex genomic regions, and phasing haplotypes. Long-read whole genome sequencing is instrumental in identifying complex genetic variations, such as structural variants and repeat expansions, which are often implicated in diseases like cancer and neurological disorders. Additionally, it enhances the accuracy of genome assemblies, facilitating a more comprehensive understanding of genetic information.Short-read whole genome sequencing
Short-read whole genome sequencing is a widely used genomic technology that sequences DNA in small fragments (typically 100-300 bp) with high accuracy and throughput. Short-read whole genome sequencing is widely used in clinical diagnostics to detect single nucleotide variants, insertions/deletions, and copy number changes, aiding in the identification of genetic disorders and informing personalized treatment plans. Additionally, it plays a crucial role in pathogen surveillance by identifying bacterial species and antimicrobial resistance genes, which is essential for managing infectious diseases and tracking outbreaks. CATG utilizes Illumina’s NextSeq 2000 sequencing platform to provide cost-effective and scalable genome analysis, making it ideal for a range of research and clinical applications.Whole exome sequencing
Whole exome sequencing (WES) on NextSeq 2000 Illumina sequencing platform is a targeted genomic approach that sequences only the protein-coding regions (exons) of the genome, which make up about 1-2% of the genome but contain ~85% of known disease-related variants. By focusing on these regions, WES provides a cost-effective and efficient method for identifying genetic mutations linked to disease.
Transcriptomics
Bulk transcriptomics
CATG offers bulk transcriptomics services by long-read sequencing platforms—PacBio Revio and Oxford Nanopore Technologies (ONT). These platforms enable in-depth, full-length transcriptome profiling from complex samples, providing an unparalleled view of isoform diversity, alternative splicing, gene fusions, and transcript-level expression.Single-cell transcriptomics
10x Genomics single-cell technology at CATG enables high-throughput analysis of individual cells, providing deep insights into cellular heterogeneity, gene expression, and immune responses. Using the microfluidics-based Chromium X controller platform, it partitions thousands to millions of cells, capturing their molecular profiles with high precision. Single-cell sequencing can be carried out with PacBio Revio, Oxford-nanopore and Illumina platforms.
Liquid-Chromatography Mass Spectrometry-based Metabolomics
We provide high-resolution metabolomics analysis to study small molecules such as lipids, amino acids, and metabolic intermediates.
Technology
Powered by advanced LC-MS platforms, enabling accurate and comprehensive profiling of complex biological samples.
Sample Types
Compatible with a wide range of samples, including cells, blood plasma, and other aqueous biological materials.
Approaches
- Discovery metabolomics: Identifies a broad range of metabolites without prior assumptions.
- Targeted metabolomics: Precisely measures specific metabolites and biomarkers.
Applications
Supports research in metabolism, disease mechanisms, and therapeutic response.
Liquid-Chromatography Mass Spectrometry-based Proteomics
We provide advanced proteomics analysis to study thousands of proteins or focus on specific targets within a sample.
Technology
Powered by high-resolution LC-MS platforms, enabling accurate identification and quantification of proteins, peptides, and post-translational modifications.
Approaches
- Discovery proteomics: Enables comprehensive analysis of protein expression across samples.
- Targeted proteomics: Focuses on precise measurement of selected proteins.
Capabilities
Supports both top-down (intact proteins) and bottom-up (peptides) workflows, including protein interaction analysis such as immuno-pulldown studies.
Applications
Supports research in disease and drug mechanisms, biomarker discovery, and diagnostic and prognostic development.
The SomaScan® Proteomics
We offer advanced protein analysis using SomaScan® technology to measure thousands of proteins from a single sample.
Technology
Powered by Somamer® reagents, enabling highly sensitive and specific detection of up to 11,000 proteins, even in complex samples.
Sample Types
Ideal for challenging sample types such as blood plasma and cerebrospinal fluid (CSF).
Capabilities
Enables large-scale protein profiling to detect subtle biological changes and uncover novel biomarkers.
Applications
Supports biomarker discovery, disease understanding, drug development, and clinical diagnostics.
Bioinformatics & Data Science
We provide advanced bioinformatics and big data analysis to support genomics and multi-omics research.
Expertise
Our team specializes in long-read and short-read genomic data analysis, software development, and custom pipeline design.
Technology
We apply artificial intelligence and machine learning to interpret complex biological data and uncover meaningful insights.
Applications
Supports research in gene expression, cellular biology, and drug development.
Genetic Counseling
Expertise
Our licensed genetic counselor provides clear guidance on clinical, medical, and personal implications of genetic results.
Support
We help individuals and families make informed decisions with personalized, confidential guidance.
Applications
Supports risk assessment, diagnosis understanding, and personalized care planning.
