This course, together with other organ-system courses in Phase 2, prepares the learner for clinical clerkships in the next Phase (Phase 3) of the program. The course addresses physiological and pathological changes which occur in a variety of gastro-intestinal diseases. The focus is on correlating structural pathophysiological changes with symptoms, signs, and radiological abnormalities which accompany common gastro- intestinal diseases and the various approaches for treatment. This course also centers on the basic principles of nutrition in health and disease based on the knowledge of nutrient classes, their functions, sources and deficiency symptoms. Teaching approaches will facilitate in the learner, the development of effective communication with patients and simulated patients, independent learning, and effective team working.